Drug–Grapefruit Juice Interactions
نویسندگان
چکیده
منابع مشابه
Grapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
متن کاملAn overview of interactions between grapefruit juice and drugs
Because grapefruit contains fibre, vitamin C, antioxidants and phytochemicals, the fruit and its juice are consumed widely to help meet daily nutritional requirements. However, in the past 15 years, studies have shown that grapefruit juice can induce a several-fold increase in the plasma levels of particular drugs that can result in increased therapeutic or even toxic effects. The effect seems ...
متن کاملPomegranate juice: a heart-healthy fruit juice.
Pomegranate juice is a polyphenol-rich fruit juice with high antioxidant capacity. In limited studies in human and murine models, pomegranate juice has been shown to exert significant antiatherogenic, antioxidant, antihypertensive, and anti-inflammatory effects. Pomegranate juice significantly reduced atherosclerotic lesion areas in immune-deficient mice and intima media thickness in cardiac pa...
متن کاملGrapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs.
Concomitant administration of grapefruit juice can increase the plasma concentration of numerous drugs in humans and decrease the concentration of a few others. Such elevations of drug plasma concentrations have, on occasion, resulted in adverse clinical effects. Increased concentrations are primarily mediated by chemicals in grapefruit juice, which inhibit the CYP 3A4 drug-metabolizing enzyme ...
متن کاملInteractions of herbs and food products with drugs Grapefruit juice as an example
Plants have been used throughout human history for their medicinal properties and herbal medicines are popular worldwide. Since, all herbal medicines are mixtures of more than one active ingredient, such combinations of many substances obviously increase the likelihood of interactions taking place. Although herbal medicines have been used as remedies for number of illnesses, many of them have s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2000
ISSN: 0025-6196
DOI: 10.4065/75.9.933